In an effort to greatly expand accessibility, this compact fluorescence-guided surgery system, evaluated in mice, is crafted from cost-effective and off-the-shelf components.
Genetic diversity is key to survival in an everchanging environment. Cancer cells 鈥� thanks to their abundant and eclectic mix of mutations 鈥� unfortunately excel at surviving.聽Drug treatments can diminish tumors for a time but, in many cases, give rise to resistant cells. A different drug may eliminate the resistant population during follow-up treatment only to leave behind a new resistant line that continues to proliferate.
Releasing a drug selectively in specific locations in the body, including the brain, has been challenging. Researchers at the University of Utah have tackled the problem by designing ultrasound-sensitive nanoparticles that release a drug at the targeted site when activated by focused ultrasound.
NIH awarded more than $4 million in funds and support services to three diagnostic technology developers as part of the RADx Tech鈥檚 Advanced Platforms for HIV Viral Load Monitoring program.
Typical diagnosis of upper urinary tract cancers requires removal of suspicious tissue with forceps, a technically challenging procedure that only samples one region of the organ. NIBIB-funded researchers are developing preclinical microgrippers that could be deployed throughout the upper urinary tract, which could potentially grab tiny pieces of tissue at hundreds of different areas and someday facilitate early detection of disease.
Researchers from Washington University in St. Louis have used ultrasound to nudge rodents into an energy-conserving state that mirrors a natural, hibernation-like survival mechanism known as torpor. The technique could help buy precious time for patients in critical care.
Nanozymes鈥攁rtificial enzymes that can carry out pre-determined chemical reactions鈥攃ould selectively activate a cancer drug within a tumor while minimizing damage to healthy tissue in a mouse model of triple negative breast cancer.
New study identifies concerning gaps between how human radiologists score the accuracy of AI-generated radiology reports and how automated systems score them.
Suvranu De, dean of the FAMU-FSU College of Engineering, is building a better simulator 鈥� one that uses brain stimulation to improve learning for physicians undergoing training for robotic surgeries for oral cancers.
NIH's RADx Tech committed resources in early 2022 for increased accessibility of COVID-19 home tests. The RADx Tech Accessibility Program subsequently invited collaboration from advocacy organizations to contribute to design insights and is a first step that will help manufacturers address the gap in accessible test availability.
For most of our tissues and cells, a lack of oxygen, or hypoxia, is bad news. However, cancer cells can thrive in these conditions, rendering tumors less susceptible to anti-cancer treatments including radiation. Now, new research may offer a way to break through cancer鈥檚 hypoxia-induced defenses.
This fully wireless ultrasound patch, which can capture detailed medical information and wirelessly transmit the data to a smart device, could represent a major step forward in at-home health care technology.
A soft robotic glove is lending a 鈥渉and鈥� and providing hope to piano players who have suffered a disabling stroke. Combining flexible tactile sensors, soft actuators and AI, this robotic glove is the first to 鈥渇eel鈥� the difference between correct and incorrect versions of the same song and to combine these features into a single hand exoskeleton. Unlike prior exoskeletons, this new technology provides precise force and guidance in recovering the fine finger movements required for piano playing and other complex tasks.
Researchers have shown that an automated cancer diagnostic method, which pairs cutting-edge ultrasound techniques with artificial intelligence, can accurately diagnose thyroid cancer, of which there are more than 40,000 new cases every year.
Tissue engineering research has shown that a skin cell type could be a new therapeutic target to accelerate the healing of burns and possibly other wounds.
Researchers from Rice University have created drug-filled microparticles that can be engineered to degrade and release their therapeutic cargo days or weeks after administration. By combining multiple microparticles with different degradation times into a single injection, the researchers could develop a drug formulation that delivers many doses over time.
NIH-funded researchers developed an online tool that can analyze self-collected, at-home videos with a smartphone. When deployed in a nationwide study, the tool could predict physical health and osteoarthritis of the knee or hip.
Bioengineers from Columbia University are developing a pipeline to systematically evaluate how bacterial treatments might synergize with existing anti-cancer therapies in preclinical models.
Human brain atlases can be used by medical professionals to track normative trends over time and to pinpoint crucial aspects of early brain development. By using these atlases, they are able to see what typical structural and functional development looks like, making it easier for them to spot the symptoms of abnormal development, such as attention-deficit / hyperactivity disorder (ADHD), dyslexia, and cerebral palsy.
After years of research, an NIH-funded team has developed a wearable cardiac ultrasound imager that can non-invasively capture real-time images of the human heart. The prototype patch, which is about the size of a postage stamp, can be worn during exercise, providing valuable cardiac information when the heart is under stress.
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