Wistar Institute scientists and collaborators describe a next-generation vaccination technology that combines plasmid DNA with a lipid nanoparticle delivery system.
Existing antivirals may be less effective against this H5N1 bird flu strain, and prevention measures, such as avoiding raw milk consumption and reducing exposure in dairy workers, may be the most effective way to protect against the virus.
Study findings provide a new gene pathway for potential treatment of the virus affecting millions
More than 90% of the adult population in the U.S. is or has been infected with Epstein Barr virus (EBV). EBV is a highly contagious member of the herpes virus family, best known for causing infectious mononucleosis ("mono") and for its association with several cancers and autoimmune diseases. Kidney transplant patients who鈥檝e never been exposed to EBV but receive organs from a donor who carried the virus may develop a life-threatening post-transplant complication called lymphoproliferative disorder (PTLD), according to a new study from the Perelman School of Medicine at the University of Pennsylvania. An estimated 4 to 5 percent of adult kidney transplants 鈥� as many as 1200 patients per year 鈥� could be at risk of the condition, in which the body鈥檚 immune system gets confused and immune cells can grow out of control and act like cancer. The findings were recently published in Annals of Internal Medicine.
A nasal vaccine for COVID-19 鈥� based on technology developed at Washington University in St. Louis 鈥� is poised to enter a phase 1 clinical trial in the U.S.
Federal science agencies have renewed and increased funding for a world-renowned digital archive of protein structures housed by Rutgers University-New Brunswick, an open-access data resource that has enabled research in everything from agriculture to zoology and has laid the groundwork for Nobel Prize-winning discoveries.
NIH awarded more than $4 million in funds and support services to three diagnostic technology developers as part of the RADx Tech鈥檚 Advanced Platforms for HIV Viral Load Monitoring program.
Sean Crosson, a Professor Rudolph Hugh Endowed Chair in Michigan State University鈥檚 Department of Microbiology, Genetics and Immunology, has been awarded a $2.4 million grant from the National Institutes of Health鈥檚 National Institute of Allergy and Infectious Diseases to study the cause of that very disease, Brucella abortus.
University of California San Diego School of Medicine researchers find advanced AI could lead to easier, faster and more efficient hospital quality reporting.
The question isn鈥檛 if, but when, the next pandemic will hit. Research and observation have identified strong potential for the next pandemic-causing virus to come from one or more of five different virus families.
In a study of 12 participants, researchers at Beth Israel Deaconess Medical Center (BIDMC) have demonstrated that a cocktail of three broadly neutralizing antibodies (bNAb) successfully suppressed virus in people living with HIV. A subset of participants also demonstrated long-term control of the virus months after antibody levels declined to low or undetectable.
The annual influenza vaccination provides updated protection against the virus but could be improved as there is large variability in its efficacy.
A two-year study found that spikes of post-vaccination SARS-CoV-2 viral infections (commonly known as COVID-19 breakthrough cases) remain common, yet hospitalization rates have dramatically dropped following the first wave of the virus鈥� omicron subvariant.
St. Jude Children鈥檚 Research Hospital scientists found that immune cells present in individuals long before influenza infection predict whether the illness is symptomatic.
Researchers at UT Southwestern Medical Center have identified a novel parameter of T cells that could help oncologists anticipate which patients would be most likely to develop immunotherapy toxicity. The findings, published in the Journal for ImmunoTherapy of Cancer, could lead to improved treatments for a variety of cancers.
The bacterium commonly referred to as C. diff is sometimes called 鈥淐-difficult鈥� because it is so hard to treat, said Mohamed Seleem, director of the Center for One Health Research. Seleem and Nectagen Inc. have received a nearly $275,000 grant from the National Institute of Allergy and Infectious Diseases to study whether synthetic proteins developed by Nectagen can reduce the toxicity of the digestive bacteria.
A metabolic by-product that is more prevalent during fasting may supercharge immune cells as they fight infection and disease, reports an early stage study by Van Andel Institute scientists and collaborators.
While the incidence of influenza-associated neuropsychiatric events in children in the United States is unknown, the controversy over the use of a common antiviral medication typically administered to treat flu in children has sparked concern among parents and medical professionals alike. The dilemma about whether the treatment causes neuropsychiatric events or if the infection itself is the culprit, led a group of pediatric researchers at Monroe Carell Jr.
ASBMB publishes a statement expressing concerns for NIH budget cuts outlined by a House Labor HHS funding bill that could lead to lost jobs and halted research progress
Scientists have long used community advisory boards to engage communities and provide feedback on studies, but this model has limitations. Now, Wistar Institute researchers are sharing how a more inclusive model for community engagement can lead to deeper insights and greater community participation in HIV research.
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