Most patients with Alzheimer's disease and Alzheimer's Disease Related Dementias (ADRD) experience the gradual onset and progression of cognitive symptoms, leading to decline over years or decades. However, in a small subset of patients, symptoms begin rapidly, leading to dementia within one year and complete incapacitation within two years of symptom onset.
Stroke survivors who have attended some level of higher education may face even steeper mental declines, according to a study led by Michigan Medicine. The findings suggest that attending higher education may enable people to retain greater cognitive ability until a critical threshold of brain injury is reached after a stroke.
Just a few days of eating a diet high in saturated fat could be enough to cause memory problems and related brain inflammation in older adults, a new study in rats suggests.
Researchers from Cleveland Clinic鈥檚 Genome Center outlined the pathway human herpes simplex virus-1 (HSV1) can use to contribute to Alzheimer鈥檚 disease in aging brains. In a report published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, investigators also share two FDA-approved, commercially available drugs that reverse this pathway in a laboratory setting. The findings are the first concrete evidence to support the previously controversial link between human herpesviruses (HHVs) and Alzheimer鈥檚 disease.
U.S. outpatient prescriptions for hydroxychloroquine and ivermectin increased 2- to 10-fold above pre-pandemic rates, respectively, to treat COVID-19, despite strong evidence disproving their effectiveness.
The number of family caregivers supporting older adults living in home and residential-care settings increased 32%, from 18.2 million to 24.1 million, between 2011 and 2022, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health and the University of Michigan鈥檚 Institute for Social Research.
Nearly seven million Americans are living with dementia, and the number of individuals with cognitive impairment is expected to rise with the current acceleration of population aging.
Improved patterns of anti-diabetic medication use and declining rates of various life-threatening acute diabetes complications are closing the disparities gap for American Indian and Alaska Native populations with Type 2 diabetes.
A Wayne State University School of Medicine faculty member has been awarded a total of $2.3 million by the National Institute on Aging of the National institutes of Health for two new, concurrent projects that both address questions related to Alzheimer鈥檚 disease, a progressive, age-related degenerative brain disease characterized by memory problems, impaired judgment, cognitive issues and changes in personality.
People in early middle age who have poor sleep quality, including having difficulty falling or staying asleep, have more signs of poor brain health in late middle age, according to a study published in the October 23, 2024, online issue of Neurology庐, the medical journal of the American Academy of Neurology.
New research led by Florida State University College of Medicine faculty quantified the association between loneliness and dementia by analyzing data from more than 600,000 people around the world 鈥� the largest study of its kind. The meta-analysis of 21 longitudinal studies showed that experiencing feelings of loneliness increased the risk of developing dementia by 31%.
Rensselaer Polytechnic Institute (RPI) has been awarded two grants by the National Institute on Aging (NIA) to train graduate students on Alzheimer鈥檚 disease (AD) research and commercialization. NIA is one of the National Institutes of Health in the U.S. Department of Health and Human Services and is the primary federal agency supporting and conducting AD research.
Psychiatric drugs are reported to be about 50% more effective in clinical trials funded by the drug鈥檚 manufacturer than when trials of the same drug are sponsored by other groups, new research shows.
A study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) found the risk of developing Parkinson鈥檚 disease was 76 percent higher among those with a history of damage to the lining of their upper gastrointestinal (GI) tract than among those without.
Vaginal estrogen cream, which is commonly prescribed to help women after surgery for pelvic organ prolapse (POP), did not prevent a recurrence of the condition, according to results of a multicenter clinical trial led by UT Southwestern Medical Center. However, the medication did reduce symptoms of vaginal atrophy. The findings, reported in JAMA, could lead to new ways to improve outcomes of prolapse repairs, the study authors said.
Needs related to housing, transportation, food, social support and more can be identified through AI/ML techniques.
People with chronic pain who take opioids have trouble finding multimodal pain care; insurance and provider education changes are needed, experts say.
With a $16 million grant from the National Institute on Aging, the University of California, San Francisco and the University of California, Irvine will work with community partners to improve the representation of Asian American, Native Hawaiian and Pacific Islander adults in research on aging, caregiving, and Alzheimer鈥檚 disease and related dementias.
New research in colorectal cancers directed by investigators at the Johns Hopkins Kimmel Cancer Center suggests that expression of transcription factors 鈥� proteins that help turn specific genes on or off by binding to nearby DNA 鈥� may play a central role in the degree of DNA methylation across the genome, contributing to the development of different subtypes of these cancers. Methylation is a process in which certain chemical groups attach to areas of DNA that guide genes鈥� on/off switches.
People who carry the gene variant associated with the strongest risk for Alzheimer鈥檚 disease may lose their ability to detect odors earlier than people who do not carry the gene variant, which may be an early sign of future memory and thinking problems, according to a study published in the July 26, 2023, online issue of Neurology庐, the medical journal of the American Academy of Neurology. The gene variant associated with this increased risk of Alzheimer鈥檚 is called APOE e4.
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